Recent Workshop

Evidence-based Toxicology for the 21st Century:  Opportunities and Challenges
U.S. Environmental Protection Agency
Research Triangle Park, North Carolina
January 24-25, 2012

Sponsored by:

Program (as of Jan. 19, 2012)

Day 1 (Tuesday, January 24th)

9:15 - 10:00
Registration and Continental Breakfast  

10:00             
Opening Remarks

10:00
Robert Kavlock (U.S. Environmental Protection Agency) - Welcome

10:10
Martin Stephens (Johns Hopkins University) – Evidence-based Toxicology for the 21st Century

10:30             
Session 1: Perspectives on Validation of High-throughput Pathway-based Assays Supporting the 21st Century Toxicity Testing Vision
Chair: Carl Westmoreland (Unilever)
Rapporteur: Sebastian Hoffmann (seh consulting + services)

Richard Judson (U.S.  Environmental Protection Agency)
           
11:15
Discussants:

• Doug Wolf (U.S. Environmental Protection Agency)
• Ed Carney (Dow)
• Grace Tier (DuPont)

12:15             
Lunch

1:15               
Open Discussion                               

2:15               
Session 2: Case Studies of Past and Current Evidence-based Toxicology-related Activities
Chair: James Freeman (ExxonMobil)
Rapporteur: Melvin Andersen (The Hamner Institutes for Health Science)

Ellen Silbergeld (Johns Hopkins University)
Being Careful What We Wish For: the Opportunities and Responsibilities of Evidence-based Toxicology

Daland Juberg (Dow Agrosciences)
Defining and Distinguishing Adversity from Adaptability in 21st Century Toxicology

Patricia Harlow (US Food and Drug Administration)
The Qualification of Safety Biomarkers at CDER

3:15               
Break

3:45               
Discussants:

• Robert Chapin (Pfizer)
• Kim Boekelheide (Brown University)
• Richard Judson (US Environmental Protection Agency)

4:45               
Open Discussion

5:45 - 6:30               
Reception

7:00               
Adjourn

Day Two (January 25th)

800 - 8:30
Continental Breakfast

8:30               
Session 3:  Setting Priorities for the Evidence-based Toxicology Collaboration
Chair: Rodger Curren (Institute for In Vitro Sciences)
Rapporteur: Abigail Jacobs (US Food and Drug Administration)
             
Suzanne Fitzpatrick (U.S. Food and Drug Administration)

9:00               
Discussants:  

• Timothy Pastoor (Syngenta)
• Olga Naidenko (Environmental Working Group)
• Michael Holsapple (Battelle)

10:30              
Break

11:00             
Open Discussion

12:00              
Lunch

1:00               
Session 4: Governance and Work Processes of the Evidence-Based Toxicology Collaboration
Chair: Francis Kruszewski (American Cleaning Institute)
Rapporteur: Joanne Zurlo (Johns Hopkins University)
             
Jack Fowle (Retired, US Environmental Protection Agency)

1:45               
Discussants:  

• Roberta Scherer (Cochrane Collaboration & Johns Hopkins)
• Rashid Shaikh (Health Effects Institute)
• Dennis Devlin (Exxon Mobil, HESI board member)
• Andrew Rowan (Human Toxicology Project Consortium)

2:45               
Open Discussion

3:45               
Next Steps for the Evidence-based Toxicology Collaboration Martin Stephens (John Hopkins University)
           
4:00               
Adjourn